ZCCHC14

Across TCGA cell cohorts, ZCCHC14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,089 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC14-associated GO terms across cancer lineages are Nuclear export, mRNA alternative polyadenylation, and Regulation of cell cycle G1/S phase transition. Each is linked with ZCCHC14 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZCCHC14-to-partner and partner-to-ZCCHC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by ZCCHC14-low versus ZCCHC14-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC14→partner) and Y-score (partner→ZCCHC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nuclear export →	+0.071	+0.626	<.001	<.001	3	16
BONE	mRNA alternative polyadenylation →	+0.096	+0.905	<.001	.001	3	15
URINARY_TRACT	Regulation of cell cycle G1/S phase transition →	+0.060	+0.714	.001	.002	3	15
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.064	+0.931	.002	.005	3	15
LUNG_NSCLC_LUSC	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.129	+1.188	.002	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.084	+0.990	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,089 associations by consensus.

Nuclear export by ZCCHC14 expression — LARGE_INTESTINE

Explore this box plot interactively →