ZCCHC14

Across TCGA cell cohorts, ZCCHC14 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZCCHC14-associated genes across cancer lineages are CBLIF, C6orf118, and CSN1S1. Each is linked with ZCCHC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC14-to-partner and partner-to-ZCCHC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by ZCCHC14-low versus ZCCHC14-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC14→partner) and Y-score (partner→ZCCHC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CBLIF →	+0.067	+4.192	<.001	.003	3	2
LARGE_INTESTINE	C6orf118 →	+0.114	+3.015	<.001	<.001	3	2
BLOOD_Lymphoma	CSN1S1 →	+0.050	+3.927	.004	.004	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
SKIN	DAZ3 →	+0.666	+3.793	<.001	.007	3	1
OVARY	CFC1B →	+0.265	+3.990	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

CBLIF by ZCCHC14 expression — BLOOD_Lymphoma

Explore this box plot interactively →