Across TCGA patient cohorts, ZCCHC13 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZCCHC13-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FoxM1. Each is linked with ZCCHC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZCCHC13-to-partner and partner-to-ZCCHC13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZCCHC13→partner) and Y-score (partner→ZCCHC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+2.000	.044	.032	3	2
UCEC	A-Raf_pS299 →	-0.116	-3.169	.031	.019	3	1
UCEC	FoxM1 →	+0.296	+3.807	.011	<.001	3	1
UCEC	INPP4B →	-0.348	-3.459	.016	.005	3	1
UCEC	JNK2 →	+0.317	+3.469	<.001	.002	3	1
UCEC	mTOR_pS2448 →	-0.157	-3.150	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ZCCHC13 survival (RNA) · tumor vs normal (RNA) · all ZCCHC13 data types