ZC3HC1

Across TCGA pan-cancer cohorts, ZC3HC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZC3HC1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZC3HC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZC3HC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where ZC3HC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.730	0.960	<.001	56	view →
HNSC	DFS	Median	All	0.264	0.886	.002	22	view →
LUAD	DFS	Tertile	All	0.944	0.796	.008	12	view →
PDAC	OS	Tertile	All	0.375	0.604	.011	10	view →
OV	DFS	Median	All	1.000	0.864	.048	4	view →
UCEC	OS	Quartile	All	0.913	1.000	.032	4	view →
GBM	OS	Tertile	All	0.520	0.318	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZC3HC1–CCRCC (OS)

Open the CCRCC breakdown →