ZC3HC1

Across TCGA patient cohorts, ZC3HC1 mutation is significantly associated with the RNA expression of many other genes, with 802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3HC1-associated genes across cancer lineages are SNORD116-29, RPL23AP82, and SNORD116-3. Each is linked with ZC3HC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3HC1-to-partner and partner-to-ZC3HC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-29 grouped by ZC3HC1-low versus ZC3HC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3HC1→partner) and Y-score (partner→ZC3HC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD116-29 →	+0.335	+2.851	<.001	.007	3	3
UCEC	RPL23AP82 →	+0.459	+3.191	.001	.009	3	2
UCEC	SNORD116-3 →	+0.284	+2.714	<.001	.005	3	2
UCEC	SBDSP1 →	+0.881	+3.467	<.001	.002	3	2
UCEC	RNA5SP415 →	+0.429	+2.351	.004	.006	3	2
BLCA	MIR4449 →	+0.535	+2.639	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 802 associations by consensus.

SNORD116-29 by ZC3HC1 expression — BLCA

Explore this box plot interactively →