ZC3HC1

Across TCGA patient cohorts, ZC3HC1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible ZC3HC1-associated genes across cancer lineages are CLP, Platelets, and Keratinocytes. Each is linked with ZC3HC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3HC1-to-partner and partner-to-ZC3HC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLP grouped by ZC3HC1-low versus ZC3HC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3HC1→partner) and Y-score (partner→ZC3HC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLP →	+0.091	+3.341	.024	.005	3	1
BLCA	Platelets →	+0.016	+2.129	.012	.035	3	1
BLCA	Keratinocytes →	-0.072	-2.964	.006	.037	2	1
BLCA	Sebocytes →	-0.070	-2.992	.032	.036	2	1
UCEC	Plasma cells →	-0.022	-2.764	.018	.003	2	1
UCEC	Class-switched memory B-cells →	-0.062	-2.807	.013	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLP by ZC3HC1 expression — SKCM

Explore this box plot interactively →