ZC3HAV1

Across TCGA pan-cancer cohorts, ZC3HAV1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZC3HAV1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZC3HAV1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZC3HAV1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where ZC3HAV1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.337	0.908	.002	14	view →
HNSC	DFS	Tertile	II,III,IV	0.971	0.868	.027	13	view →
CCRCC	OS	Median	All	0.903	1.000	.013	4	view →
GBM	OS	Median	All	0.272	0.537	.033	4	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZC3HAV1–LUAD (OS)

Open the LUAD breakdown →