ZC3HAV1

Across TCGA patient cohorts, ZC3HAV1 mutation is significantly associated with the RNA expression of many other genes, with 2,959 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3HAV1-associated genes across cancer lineages are GPX4, RNA5SP19, and RNU6-784P. Each is linked with ZC3HAV1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3HAV1-to-partner and partner-to-ZC3HAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX4 grouped by ZC3HAV1-low versus ZC3HAV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3HAV1→partner) and Y-score (partner→ZC3HAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPX4 →	+0.315	+1.874	.009	.002	3	3
READ	RNA5SP19 →	+0.546	+3.624	<.001	.004	3	2
READ	RNU6-784P →	+0.177	+3.935	<.001	.009	3	2
READ	RPL35AP3 →	+0.317	+3.364	<.001	.003	3	2
READ	CASP3P1 →	+0.052	+3.624	<.001	.004	3	2
CESC	MIR107 →	+0.276	+4.516	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,959 associations by consensus.

GPX4 by ZC3HAV1 expression — UCEC

Explore this box plot interactively →