ZC3HAV1

Across TCGA patient cohorts, ZC3HAV1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3HAV1-associated genes across cancer lineages are PKC-a, TFRC, and eIF4E. Each is linked with ZC3HAV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3HAV1-to-partner and partner-to-ZC3HAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a grouped by ZC3HAV1-low versus ZC3HAV1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3HAV1→partner) and Y-score (partner→ZC3HAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PKC-a →	-0.359	-3.000	.035	.036	3	2
UCEC	TFRC →	+0.537	+2.700	.001	.005	3	2
UCEC	eIF4E →	+0.136	+1.777	.043	.002	3	2
UCEC	VHL →	-0.855	-1.999	<.001	.002	3	2
UCEC	ATM →	-0.400	-2.102	.005	.016	3	2
BLCA	YB-1 →	-0.205	-2.982	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PKC-a by ZC3HAV1 expression — BLCA

Explore this box plot interactively →