Across TCGA pan-cancer cohorts, ZC3H6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZC3H6 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZC3H6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZC3H6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where ZC3H6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.959	0.690	.009	11	view →
PDAC	DFS	Tertile	All	0.330	0.717	.017	6	view →
GBM	DFS	Median	All	0.451	0.290	.035	3	view →
UCEC	DFS	Median	All	0.929	0.793	.035	2	view →
LUAD	OS	Quartile	II,III,IV	0.738	0.277	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZC3H6 tumor-vs-normal RNA expression · all ZC3H6 data types