Across TCGA pan-cancer cohorts, ZC3H6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZC3H6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZC3H6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZC3H6 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and OV are the cancer types where ZC3H6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC3H6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.609	<.001	8	view →
LSCC	Female	All	−0.294	<.001	8	view →
OV	All	All	−1.156	.001	2	view →
CCRCC	Male	All	+0.198	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZC3H6 RNA expression & survival · all ZC3H6 data types