Across TCGA patient cohorts, ZC3H6 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H6-associated genes across cancer lineages are ATM, Notch1, and Annexin-1. Each is linked with ZC3H6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H6-to-partner and partner-to-ZC3H6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H6→partner) and Y-score (partner→ZC3H6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.629	-2.263	<.001	<.001	3	3
COAD	Notch1 →	+0.244	+2.815	.016	.036	2	3
UCEC	Annexin-1 →	+0.537	+2.434	.001	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.167	+2.815	.007	.036	3	2
UCEC	c-Met_pY1235 →	+0.048	+1.392	.049	.019	3	2
UCEC	14-3-3_beta →	-0.086	-1.780	.009	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

ZC3H6 survival (RNA) · tumor vs normal (RNA) · all ZC3H6 data types