ZC3H4

Across TCGA pan-cancer cohorts, ZC3H4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZC3H4 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZC3H4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZC3H4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where ZC3H4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.711	1.000	.001	74	view →
COAD	DFS	Median	II,III,IV	1.000	0.886	.027	30	view →
LUAD	OS	Tertile	III,IV	1.000	0.607	.008	20	view →
GBM	OS	Quartile	All	0.545	0.260	.008	9	view →
PDAC	DFS	Quartile	II,III,IV	0.480	0.670	.013	5	view →
CCRCC	DFS	Quartile	II,III,IV	0.827	0.439	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZC3H4–HNSC (DFS)

Open the HNSC breakdown →