ZC3H4

Across TCGA patient cohorts, ZC3H4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,900 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZC3H4-associated genes across cancer lineages are ACYP1, TEX10, and USP21. Each is linked with ZC3H4 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZC3H4-to-partner and partner-to-ZC3H4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZC3H4 versus ACYP1 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H4→partner) and Y-score (partner→ZC3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACYP1 →	+0.799	+0.193	<.001	<.001	3	6
LSCC	TEX10 →	+0.546	+0.201	<.001	<.001	3	6
UCEC	USP21 →	+0.566	+0.182	.003	<.001	3	6
LSCC	FUBP1 →	+0.382	+0.174	.004	.003	3	6
LSCC	ZBTB39 →	+0.615	+0.140	<.001	.002	3	6
HNSC	FUZ →	+0.894	+0.222	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,900 associations by consensus.

ZC3H4 vs ACYP1 — LSCC

Explore this scatter interactively →