ZC3H4

Across TCGA patient cohorts, ZC3H4 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H4-associated genes across cancer lineages are ACC_pS79, ACC1, and Cyclin-B1. Each is linked with ZC3H4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H4-to-partner and partner-to-ZC3H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ZC3H4-low versus ZC3H4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H4→partner) and Y-score (partner→ZC3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.282	+1.765	.005	.011	3	3
UCEC	ACC1 →	+0.324	+1.152	.002	.048	3	3
UCEC	Cyclin-B1 →	+0.419	+2.415	.010	.002	3	3
STAD	Dvl3 →	-0.211	-3.169	.010	.019	3	2
UCEC	eEF2 →	+0.341	+2.906	.001	.001	3	2
UCEC	eIF4E →	+0.192	+3.392	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ACC_pS79 by ZC3H4 expression — UCEC

Explore this box plot interactively →