ZC3H4

Across TCGA cell cohorts, ZC3H4 mutation is significantly associated with the RNA expression of many other genes, with 462 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H4-associated genes across cancer lineages are AVP, ARL6, and MAGEB4. Each is linked with ZC3H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H4-to-partner and partner-to-ZC3H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by ZC3H4-low versus ZC3H4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H4→partner) and Y-score (partner→ZC3H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AVP →	+0.097	+4.977	<.001	.002	3	2
LARGE_INTESTINE	ARL6 →	+0.596	+3.212	<.001	.006	3	2
SKIN	MAGEB4 →	+0.010	+5.022	<.001	.002	3	2
LARGE_INTESTINE	TLR3 →	+1.152	+3.212	<.001	.006	3	2
LARGE_INTESTINE	S100G →	+0.825	+2.688	.001	.002	3	2
LARGE_INTESTINE	NUPR2 →	+0.176	+2.688	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 462 associations by consensus.

AVP by ZC3H4 expression — SOFT_TISSUE

Explore this box plot interactively →