ZC3H3

Across TCGA pan-cancer cohorts, ZC3H3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZC3H3 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ZC3H3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZC3H3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

KICH, UCEC, and LUAD are the cancer types where ZC3H3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
UCEC	DFS	Median	All	1.000	0.828	.009	16	view →
LUAD	DFS	Median	II,III,IV	0.242	0.725	.001	6	view →
SCLC	OS	Median	II,III,IV	1.000	0.399	.047	3	view →
HNSC	OS	Median	III,IV	0.365	0.748	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZC3H3–KICH (OS)

Open the KICH breakdown →