ZC3H3

Across TCGA patient cohorts, ZC3H3 protein abundance is significantly associated with the RNA expression of many other genes, with 5,818 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ZC3H3-associated genes across cancer lineages are CEACAM3, CXCR1, and FFAR2. Each is linked with ZC3H3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H3-to-partner and partner-to-ZC3H3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZC3H3 versus CEACAM3 in LSCC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H3→partner) and Y-score (partner→ZC3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEACAM3 →	+0.570	+0.835	<.001	<.001	3	4
PDAC	CXCR1 →	+1.014	+1.661	<.001	<.001	3	4
HNSC	FFAR2 →	+1.107	+0.539	.002	.004	2	4
HNSC	CMTM2 →	+0.612	+0.854	.001	<.001	3	3
LSCC	MEFV →	+0.684	+0.764	<.001	<.001	3	3
LUAD	AQP9 →	+1.156	+0.930	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,818 associations by consensus.

ZC3H3 vs CEACAM3 — LSCC

Explore this scatter interactively →