ZC3H3

Across TCGA patient cohorts, ZC3H3 mutation is significantly associated with the RNA expression of many other genes, with 1,902 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H3-associated genes across cancer lineages are MIR550A1, ZNF479, and RNU6-517P. Each is linked with ZC3H3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H3-to-partner and partner-to-ZC3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR550A1 grouped by ZC3H3-low versus ZC3H3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H3→partner) and Y-score (partner→ZC3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR550A1 →	+0.212	+1.866	.009	.005	3	4
STAD	ZNF479 →	+0.430	+3.654	<.001	.007	3	3
BLCA	RNU6-517P →	+0.457	+4.376	<.001	.002	3	3
STAD	UBE2DNL →	+0.295	+3.199	<.001	.005	3	3
SKCM	CRYBB2P1 →	+0.399	+3.635	.003	.001	3	3
UCEC	SLIRP →	+0.334	+1.617	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,902 associations by consensus.

MIR550A1 by ZC3H3 expression — SKCM

Explore this box plot interactively →