ZC3H3

Across TCGA patient cohorts, ZC3H3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H3-associated genes across cancer lineages are PKC-b-II_pS660, RAD51, and ETS-1. Each is linked with ZC3H3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H3-to-partner and partner-to-ZC3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by ZC3H3-low versus ZC3H3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H3→partner) and Y-score (partner→ZC3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.522	-3.000	.001	.035	3	3
COAD	RAD51 →	+0.181	+2.178	.014	.035	2	4
UCEC	ETS-1 →	+0.260	+2.584	.020	.010	3	3
COAD	TAZ →	+0.257	+2.195	.005	.034	3	2
COAD	XRCC1 →	+0.159	+2.840	.006	.033	3	2
COAD	CD49b →	+0.366	+3.330	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PKC-b-II_pS660 by ZC3H3 expression — COAD

Explore this box plot interactively →