ZC3H3

Across TCGA cell cohorts, ZC3H3 mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H3-associated genes across cancer lineages are WNT9B, C10orf53, and MYH6. Each is linked with ZC3H3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H3-to-partner and partner-to-ZC3H3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNT9B grouped by ZC3H3-low versus ZC3H3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H3→partner) and Y-score (partner→ZC3H3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WNT9B →	+0.073	+4.129	.001	.002	3	2
LARGE_INTESTINE	C10orf53 →	+0.006	+2.172	.009	.007	3	2
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
SOFT_TISSUE	SPACA1 →	+0.017	+4.977	<.001	.002	3	1
SOFT_TISSUE	LYZL6 →	+0.014	+4.369	<.001	.008	3	1
LIVER	TBX22 →	+0.040	+4.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

WNT9B by ZC3H3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →