ZC3H15

Across TCGA patient cohorts, ZC3H15 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H15-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and EGFR. Each is linked with ZC3H15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H15-to-partner and partner-to-ZC3H15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZC3H15-low versus ZC3H15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H15→partner) and Y-score (partner→ZC3H15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.360	+3.906	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.807	.036	.027	3	1
UCEC	EGFR →	-0.168	-1.807	.010	.027	3	1
UCEC	Lck →	+0.321	+2.321	<.001	.006	3	1
UCEC	MEK1 →	+0.340	+1.807	.024	.027	3	1
UCEC	Notch1 →	+0.167	+1.750	.003	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by ZC3H15 expression — UCEC

Explore this box plot interactively →