ZC3H14

Across TCGA pan-cancer cohorts, ZC3H14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZC3H14 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZC3H14 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZC3H14 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and CCRCC are the cancer types where ZC3H14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	1.000	0.755	.028	30	view →
UCEC	DFS	Quartile	All	0.965	0.715	.015	14	view →
CCRCC	DFS	Quartile	All	0.869	1.000	.018	10	view →
HNSC	DFS	Tertile	IV	0.667	0.922	.028	8	view →
LSCC	OS	Tertile	II,III,IV	0.904	0.608	.018	7	view →
LUAD	OS	Median	III,IV	0.625	0.226	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZC3H14–COAD (DFS)

Open the COAD breakdown →