ZC3H14

Across TCGA patient cohorts, ZC3H14 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H14-associated genes across cancer lineages are eIF4G, p62 Lck ligand, and AMPK_pT172. Each is linked with ZC3H14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H14-to-partner and partner-to-ZC3H14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by ZC3H14-low versus ZC3H14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H14→partner) and Y-score (partner→ZC3H14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.231	+2.459	.012	.018	3	2
UCEC	p62 Lck ligand →	+0.338	+1.661	<.001	.003	3	2
UCEC	AMPK_pT172 →	+0.249	+1.362	.042	.034	3	2
UCEC	Rad50 →	-0.168	-1.378	.020	.008	3	2
UCEC	STAT3_pY705 →	-0.362	-1.706	<.001	.003	3	2
UCEC	Caspase-8 →	-0.205	-1.899	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4G by ZC3H14 expression — UCEC

Explore this box plot interactively →