ZC3H14

Across TCGA cell cohorts, ZC3H14 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H14-associated genes across cancer lineages are DNMT3A, STX16, and TRIM17. Each is linked with ZC3H14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H14-to-partner and partner-to-ZC3H14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNMT3A grouped by ZC3H14-low versus ZC3H14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H14→partner) and Y-score (partner→ZC3H14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNMT3A →	-0.925	-3.278	.001	.006	3	1
LARGE_INTESTINE	STX16 →	-0.705	-3.278	.002	.006	3	1
LARGE_INTESTINE	TRIM17 →	-0.376	-3.278	.006	.006	3	1
LARGE_INTESTINE	MT1E →	+3.099	+3.364	.001	.002	3	1
LARGE_INTESTINE	L3MBTL1 →	-0.740	-3.278	.008	.006	3	1
BLOOD_Leukemia	VSX2 →	+0.033	+3.580	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

DNMT3A by ZC3H14 expression — LARGE_INTESTINE

Explore this box plot interactively →