ZC3H14

Across TCGA cell cohorts, ZC3H14 mutation is significantly associated with the mutation status of many other genes, with 2,587 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H14-associated genes across cancer lineages are SLF2, TRPM3, and PLCB4. Each is linked with ZC3H14 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZC3H14-to-partner and partner-to-ZC3H14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLF2 grouped by ZC3H14-low versus ZC3H14-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H14→partner) and Y-score (partner→ZC3H14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLF2 →	+5.832	+5.169	<.001	<.001	1	5
BLOOD_Leukemia	TRPM3 →	+2.360	+2.741	.003	.003	1	5
LARGE_INTESTINE	PLCB4 →	+1.807	+2.179	.004	.004	1	5
CNS	ARID4A →	+4.459	+5.277	.005	.005	1	4
CNS	RBM5 →	+6.044	+6.044	.001	.001	1	4
BLOOD_Lymphoma	MYCBP2 →	+2.832	+3.601	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,587 associations by consensus.

SLF2 by ZC3H14 expression — BLOOD_Lymphoma

Explore this box plot interactively →