ZC3H13

Across TCGA pan-cancer cohorts, ZC3H13 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZC3H13 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZC3H13 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZC3H13 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where ZC3H13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.884	.025	12	view →
HNSC	OS	Quartile	III,IV	0.832	0.973	.019	11	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	11	view →
LSCC	DFS	Median	II,III,IV	0.498	0.919	.037	2	view →
GBM	OS	Quartile	All	0.568	0.254	.032	2	view →
CCRCC	OS	Median	All	0.727	1.000	.013	1	view →
LUAD	DFS	Quartile	II,III,IV	0.928	0.666	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZC3H13–COAD (DFS)

Open the COAD breakdown →