ZC3H13

Across TCGA patient cohorts, ZC3H13 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H13-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1_pT70, and GAPDH. Each is linked with ZC3H13 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZC3H13-to-partner and partner-to-ZC3H13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZC3H13-low versus ZC3H13-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H13→partner) and Y-score (partner→ZC3H13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.153	+2.708	<.001	.003	3	4
COAD	4E-BP1_pT70 →	+0.104	+2.708	.032	.003	3	3
COAD	GAPDH →	+0.555	+2.334	.006	.018	3	2
COAD	PDK1 →	-0.115	-3.169	.011	.018	3	2
COAD	TSC1 →	-0.362	-1.991	.001	.031	3	2
UCEC	eIF4E →	+0.165	+1.398	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by ZC3H13 expression — COAD

Explore this box plot interactively →