ZC3H13

Across TCGA cell cohorts, ZC3H13 mutation is significantly associated with the RNA expression of many other genes, with 1,704 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H13-associated genes across cancer lineages are ZBED4, TTC33, and GATAD2B. Each is linked with ZC3H13 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZC3H13-to-partner and partner-to-ZC3H13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBED4 grouped by ZC3H13-low versus ZC3H13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H13→partner) and Y-score (partner→ZC3H13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBED4 →	+0.557	+2.837	<.001	<.001	3	3
LARGE_INTESTINE	TTC33 →	+0.580	+2.364	.001	<.001	3	3
LARGE_INTESTINE	GATAD2B →	+0.569	+1.850	<.001	.006	3	3
LARGE_INTESTINE	ZBTB39 →	+0.441	+1.850	.003	.006	3	3
LARGE_INTESTINE	CBX2 →	+0.868	+3.459	.001	.001	3	3
LARGE_INTESTINE	GCAT →	+1.408	+3.043	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,704 associations by consensus.

ZBED4 by ZC3H13 expression — LARGE_INTESTINE

Explore this box plot interactively →