ZC3H12B

Across TCGA patient cohorts, ZC3H12B mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H12B-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with ZC3H12B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H12B-to-partner and partner-to-ZC3H12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZC3H12B-low versus ZC3H12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H12B→partner) and Y-score (partner→ZC3H12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.173	+1.369	.002	.003	3	2
UCEC	ERK2 →	+0.146	+1.206	.005	.009	3	2
UCEC	JNK2 →	+0.188	+2.129	<.001	<.001	3	2
UCEC	Notch1 →	+0.083	+1.147	.033	.025	3	2
UCEC	PDCD4 →	-0.335	-1.050	.009	.023	3	2
UCEC	Annexin-1 →	+0.445	+1.894	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by ZC3H12B expression — UCEC

Explore this box plot interactively →