ZC3H10

Across TCGA pan-cancer cohorts, ZC3H10 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZC3H10 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZC3H10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZC3H10 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where ZC3H10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	1.000	0.624	<.001	43	view →
LUAD	DFS	Quartile	II,III,IV	0.412	0.976	.018	14	view →
CCRCC	DFS	Tertile	All	0.209	0.917	.024	8	view →
PDAC	OS	Quartile	II,III,IV	0.524	0.908	.019	6	view →
GBM	OS	Median	All	0.399	0.634	.030	2	view →
HNSC	OS	Median	III,IV	0.593	0.913	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZC3H10–LSCC (OS)

Open the LSCC breakdown →