ZC3H10

Across TCGA patient cohorts, ZC3H10 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC3H10-associated genes across cancer lineages are PCNA, eEF2, and MEK1. Each is linked with ZC3H10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H10-to-partner and partner-to-ZC3H10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZC3H10-low versus ZC3H10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H10→partner) and Y-score (partner→ZC3H10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.255	+2.000	.008	.032	3	2
UCEC	eEF2 →	+0.376	+2.700	.019	.006	3	1
UCEC	MEK1 →	+0.400	+2.459	.015	.019	3	1
UCEC	MSH2 →	-0.437	-3.433	<.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.114	-2.000	.013	.032	3	1
UCEC	STAT3_pY705 →	-0.297	-2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by ZC3H10 expression — UCEC

Explore this box plot interactively →