ZC3H10

Across TCGA cell cohorts, ZC3H10 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC3H10-associated genes across cancer lineages are TLE7, GCAT, and CBY1. Each is linked with ZC3H10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC3H10-to-partner and partner-to-ZC3H10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE7 grouped by ZC3H10-low versus ZC3H10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC3H10→partner) and Y-score (partner→ZC3H10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TLE7 →	+0.016	+4.969	.003	.003	3	1
LARGE_INTESTINE	GCAT →	+1.384	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.635	+3.299	.001	.004	3	1
LARGE_INTESTINE	ASPN →	+0.039	+3.600	<.001	.001	3	1
LARGE_INTESTINE	PIGL →	+0.724	+3.212	.006	.006	3	1
LARGE_INTESTINE	EIF5A →	+0.559	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

TLE7 by ZC3H10 expression — BLOOD_Leukemia

Explore this box plot interactively →