ZC2HC1B

Across TCGA cell cohorts, ZC2HC1B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZC2HC1B-associated genes across cancer lineages are ZNF831, FBXW10, and TFDP3. Each is linked with ZC2HC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1B-to-partner and partner-to-ZC2HC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by ZC2HC1B-low versus ZC2HC1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1B→partner) and Y-score (partner→ZC2HC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	FBXW10 →	+0.206	+3.491	.003	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+2.933	<.001	.003	3	1
LARGE_INTESTINE	PNMA3 →	+0.175	+3.044	<.001	.002	3	1
LARGE_INTESTINE	BPIFA1 →	+0.156	+3.425	<.001	<.001	3	1
LARGE_INTESTINE	CLPSL1 →	+0.104	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ZNF831 by ZC2HC1B expression — LARGE_INTESTINE

Explore this box plot interactively →