ZC2HC1A

Across TCGA pan-cancer cohorts, ZC2HC1A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZC2HC1A data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher ZC2HC1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZC2HC1A expression acts as an unfavorable survival marker.

DLBC, CESC, and SARC are the cancer types where ZC2HC1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
CESC	DFS	Median	All	0.200	0.825	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZC2HC1A–DLBC (OS)

Open the DLBC breakdown →