ZC2HC1A

Across TCGA pan-cancer cohorts, ZC2HC1A mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZC2HC1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZC2HC1A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZC2HC1A is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where ZC2HC1A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZC2HC1A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.544	<.001	10	view →
HNSC	All	II,III,IV	−0.226	<.001	9	view →
LSCC	Male	II,III,IV	−0.250	<.001	7	view →
PDAC	All	II,III,IV	+0.253	<.001	6	view →
LUAD	All	All	−0.132	<.001	5	view →
OV	All	All	−0.523	.010	2	view →
CCRCC	Male	All	+0.104	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZC2HC1A–COAD

Open the COAD breakdown →