ZC2HC1A

Across TCGA patient cohorts, ZC2HC1A mutation is significantly associated with the RNA expression of many other genes, with 1,030 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC2HC1A-associated genes across cancer lineages are OR5M9, RNA5SP412, and RNU4-7P. Each is linked with ZC2HC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1A-to-partner and partner-to-ZC2HC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M9 grouped by ZC2HC1A-low versus ZC2HC1A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1A→partner) and Y-score (partner→ZC2HC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR5M9 →	+0.044	+6.763	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.606	+2.092	<.001	.007	3	2
BRCA	RNU4-7P →	+0.202	+5.571	.007	.002	3	2
HNSC	LINC00358 →	+0.061	+5.822	<.001	.003	3	2
UCEC	MIR4445 →	+0.189	+4.571	<.001	.002	3	2
COAD	RNA5SP104 →	+0.758	+4.790	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,030 associations by consensus.

OR5M9 by ZC2HC1A expression — HNSC

Explore this box plot interactively →