ZC2HC1A

Across TCGA patient cohorts, ZC2HC1A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZC2HC1A-associated genes across cancer lineages are Notch1, EGFR_pY1068, and Rictor_pT1135. Each is linked with ZC2HC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZC2HC1A-to-partner and partner-to-ZC2HC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZC2HC1A-low versus ZC2HC1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZC2HC1A→partner) and Y-score (partner→ZC2HC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.200	+3.009	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.245	-2.459	.043	.020	3	1
UCEC	Rictor_pT1135 →	-0.104	-3.584	.035	.002	3	1
UCEC	STAT3_pY705 →	-0.442	-2.999	<.001	.035	3	1
UCEC	Tuberin →	+0.303	+2.179	.019	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.835	+2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by ZC2HC1A expression — UCEC

Explore this box plot interactively →