ZBTB8OS

Across TCGA pan-cancer cohorts, ZBTB8OS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZBTB8OS data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZBTB8OS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB8OS expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where ZBTB8OS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.431	0.876	.001	38	view →
UCEC	DFS	Median	III,IV	1.000	0.424	.003	28	view →
HNSC	DFS	Median	All	0.745	0.562	.024	8	view →
LUAD	DFS	Median	All	0.466	0.832	.036	5	view →
PDAC	OS	Median	III,IV	0.317	0.768	.045	3	view →
LSCC	DFS	Tertile	II,III,IV	0.847	0.999	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZBTB8OS–CCRCC (DFS)

Open the CCRCC breakdown →