ZBTB8OS

Across TCGA patient cohorts, ZBTB8OS mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB8OS-associated genes across cancer lineages are PRKACG, OR5AC2, and SPANXA1. Each is linked with ZBTB8OS in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB8OS-to-partner and partner-to-ZBTB8OS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by ZBTB8OS-low versus ZBTB8OS-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB8OS→partner) and Y-score (partner→ZBTB8OS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKACG →	+0.054	+4.126	<.001	.005	3	1
BRCA	OR5AC2 →	+0.153	+5.201	<.001	.002	3	1
BRCA	SPANXA1 →	+0.876	+4.341	<.001	.009	3	1
BRCA	RNU6-1044P →	+0.133	+7.057	<.001	.009	3	1
BRCA	RNA5SP35 →	+0.385	+4.605	<.001	.001	3	1
BRCA	CYCSP46 →	+0.230	+4.386	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PRKACG by ZBTB8OS expression — BRCA

Explore this box plot interactively →