ZBTB7C

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZBTB7C mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB7C-associated genes across cancer lineages are MEK1, MSH2, and p90 RSK. Each is linked with ZBTB7C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB7C-to-partner and partner-to-ZBTB7C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB7C→partner) and Y-score (partner→ZBTB7C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMEK1 →+0.357+1.836.001.00132
UCECMSH2 →-0.197-1.781.006.02432
UCECp90 RSK →+0.138+1.512.022.01732
UCECPI3K-p85 →+0.142+1.710.031.02532
UCECRad50 →-0.243-2.115.001<.00132
UCECCaspase-7-cleavedD198 →+0.623+2.019<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration