ZBTB5

Across TCGA patient cohorts, ZBTB5 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB5-associated genes across cancer lineages are ERK2, JNK2, and NDRG1_pT346. Each is linked with ZBTB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB5-to-partner and partner-to-ZBTB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZBTB5-low versus ZBTB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB5→partner) and Y-score (partner→ZBTB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.201	+1.700	.005	.042	3	2
UCEC	JNK2 →	+0.163	+1.415	.028	.046	3	2
UCEC	NDRG1_pT346 →	-0.373	-2.321	.042	.033	3	2
UCEC	STAT3_pY705 →	-0.439	-2.169	<.001	.003	3	2
UCEC	ATM →	-0.565	-2.169	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.345	-3.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by ZBTB5 expression — UCEC

Explore this box plot interactively →