ZBTB5

Across TCGA cell cohorts, ZBTB5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB5-associated genes across cancer lineages are TSLP, OR10Q1, and OR56A5. Each is linked with ZBTB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB5-to-partner and partner-to-ZBTB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSLP grouped by ZBTB5-low versus ZBTB5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB5→partner) and Y-score (partner→ZBTB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSLP →	+0.676	+3.273	<.001	.006	3	1
LARGE_INTESTINE	OR10Q1 →	+0.075	+2.657	.007	.007	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
LARGE_INTESTINE	L3MBTL4 →	+1.033	+3.285	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TSLP by ZBTB5 expression — LARGE_INTESTINE

Explore this box plot interactively →