ZBTB49

Across TCGA pan-cancer cohorts, ZBTB49 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZBTB49 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZBTB49 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZBTB49 expression acts as an unfavorable survival marker.

LUAD, KICH, and COAD are the cancer types where ZBTB49 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.192	0.792	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
COAD	OS	Median	IV	0.082	0.659	<.001	12	view →
LIHC	DFS	Median	All	0.029	0.556	<.001	12	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZBTB49–LUAD (DFS)

Open the LUAD breakdown →