ZBTB49

Across TCGA patient cohorts, ZBTB49 mutation is significantly associated with the RNA expression of many other genes, with 2,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB49-associated genes across cancer lineages are PPP6C, CEP78, and TMEM138. Each is linked with ZBTB49 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZBTB49-to-partner and partner-to-ZBTB49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP6C grouped by ZBTB49-low versus ZBTB49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB49→partner) and Y-score (partner→ZBTB49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP6C →	+0.368	+2.040	.009	.005	3	3
UCEC	CEP78 →	+0.450	+3.732	.005	<.001	3	3
UCEC	TMEM138 →	+0.249	+2.673	.005	<.001	3	2
UCEC	CCT5 →	+0.535	+3.639	.005	.001	3	2
UCEC	BAG3 →	+0.577	+2.523	.001	.009	3	2
UCEC	GBP5 →	+1.198	+2.673	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,101 associations by consensus.

PPP6C by ZBTB49 expression — UCEC

Explore this box plot interactively →