ZBTB49

Across TCGA patient cohorts, ZBTB49 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZBTB49-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PCNA. Each is linked with ZBTB49 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB49-to-partner and partner-to-ZBTB49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZBTB49-low versus ZBTB49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB49→partner) and Y-score (partner→ZBTB49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.511	+3.700	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.345	+2.469	.012	.010	3	2
UCEC	PCNA →	+0.195	+1.700	.033	.044	3	2
UCEC	PDCD4 →	-0.445	-2.222	.026	.011	3	2
UCEC	ATM →	-0.620	-2.222	.001	.011	3	2
COAD	TSC1 →	-0.476	-3.169	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by ZBTB49 expression — UCEC

Explore this box plot interactively →