ZBTB49

Across TCGA cell cohorts, ZBTB49 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZBTB49-associated genes across cancer lineages are TPD52L3, KRT6C, and OR2A2. Each is linked with ZBTB49 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZBTB49-to-partner and partner-to-ZBTB49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by ZBTB49-low versus ZBTB49-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB49→partner) and Y-score (partner→ZBTB49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TPD52L3 →	+0.395	+5.266	<.001	.001	3	2
BONE	KRT6C →	+0.016	+5.169	<.001	.004	3	1
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR14C36 →	+0.015	+5.266	<.001	.001	3	1
LARGE_INTESTINE	PF4V1 →	+0.186	+2.793	.001	.002	3	1
LARGE_INTESTINE	ANGPTL8 →	+0.075	+2.782	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

TPD52L3 by ZBTB49 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →