Across TCGA pan-cancer cohorts, ZBTB48 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZBTB48 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ZBTB48 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZBTB48 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, PDAC, and LUAD are the cancer types where ZBTB48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	1.000	0.190	.002	18	view →
PDAC	DFS	Median	II,III,IV	0.812	0.285	.003	15	view →
LUAD	OS	Median	All	0.881	1.000	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZBTB48 tumor-vs-normal RNA expression · all ZBTB48 data types