Across TCGA pan-cancer cohorts, ZBTB48 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ZBTB48’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ZBTB48 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ZBTB48 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, LUAD, and LSCC are the cancer types where ZBTB48 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZBTB48 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.252	.008	4	view →
LUAD	All	III,IV	+0.381	.007	3	view →
LSCC	Female	All	+0.170	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZBTB48 RNA expression & survival · all ZBTB48 data types