ZBTB47

Across TCGA cell cohorts, ZBTB47 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,737 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZBTB47-associated GO terms across cancer lineages are Actin filament depolymerization, Negative regulation of hippo signaling, and Positive regulation of cell-substrate junction organization. Each is linked with ZBTB47 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZBTB47-to-partner and partner-to-ZBTB47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by ZBTB47-low versus ZBTB47-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZBTB47→partner) and Y-score (partner→ZBTB47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.248	+1.271	<.001	<.001	3	14
BREAST	Negative regulation of hippo signaling →	+0.074	+1.084	.007	.009	3	12
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.171	+1.023	<.001	.001	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.212	+1.377	.002	<.001	3	12
CNS	Regulation of protein K48-linked ubiquitination →	+0.086	+0.925	<.001	<.001	3	12
SOFT_TISSUE	Skeletal muscle fiber development →	+0.197	+0.842	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,737 associations by consensus.

Actin filament depolymerization by ZBTB47 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →